Ripro-genetic biotechnologies are progressively transforming what have always been “matters of fact” into “matters of concern”. The ongoing genetic revolution, indeed, raises dilemmas that natural reproduction has led us to ignore, including reframing the issue of reprodutive liberty, harm prevention, the right to an open future for the unborn child, and the principle of procreative beneficence. Of these themes, the culturally, historically and geographically specific, and therefore unstable character has often been disregarded. My research, then, aims to deal with a redefinition of the genome on which ripro‑genetic manipulation choices can be better contextualized. What kind of genetic intervention can be defined as “enhancement”? I argue that this fundamental question can be better investigated by focusing on “the political dimension of the genome”, that is the dimension characterized by those data and values produced by the dialogic process of both the cultural code and the natural code. Thus, the extension of the concrete possibility of using genome editing biotechnologies up to what internally defines us brings with it a hermeneutic task. I’m also interested in biosemiotics and code biology perspectives for the potential they offer to deepen my research.